This Week In Virology With Vincent Racaniello

Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes. Host: Vincent Racaniello Guests: Sheree Yau and Victoria Queiroz Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier 8:16 Virophage control of antarctic algal host-virus dynamics (PNAS) Timestamps by Jolene. Thanks! Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv) Two groups of pithoviruses (J Virol) Educational toolkit for virology classes (J Virol) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles everywhere (CDC) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Estimating niresevimab effectiveness for infants (MMWR) More than 100 children died of i

TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Heterosexual transmission of clade I Mpox virus (Emerg Inf Dis) Continued circulation of oropouche virus (PAHO and WHO) Herpesviruses in fur seals and sea lions (PLoS One) Sex-specific effects of SARS-CoV-2 infection (PLoS One) Drivers of 2022 Mpox virus epidemic (Cell) How AAV

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (C

TWiV discusses effectiveness of this season’s flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Effectiveness of flu vaccine (MMWR, Eurosurveill) Efficacy of Pfizer RSV vaccine (Pfizer) Understanding six types of vaccine technologies (Pfizer) nOPV in US? (CDC) Dengue in Peru (Peruvian State) Measles in Michigan and Indiana Marburg virus control by reservoir bats (Nat Commun) tRNA acquisition by phages (Cell) Viruses of Microbes 2024 Timestamps by Jolene.

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) RSV vaccination stats (CIDRAP) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 nati

TWiV reviews resurgence of Lassa fever in West Africa, at least 3 paralytic cases of cVDPV2 in Zimbabwe, CWD from eating prion-laden plants, measles in New Orleans and Broward County Florida, failure of Florida Surgeon General to support vaccination, a measles variant in Switzerland, SARS-CoV-2 persistent infections, leaky blood-brain-barrier for long COVID brain fog, West Nile virus transmitted among mosquitoes by the excreta, and viroid-like colonists of human microbiomes. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Resurgence of Lassa fever (Science) cVDPV2 in Zimbabwe (UNICEF) CWD from eating plants (CIDRAP) Measles in New Orleans (LA Dept Health

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus before discussing uptake of the RSV vaccine Abrysvo or the monoclonal anti-RSV antibody nirsevimab to prevent severe disease following RSV infection in infants 8 months or younger before going over this week’s influenza virus and SARS-CoV-2 virus statistics, including all circulating variants in the US, examines if self-testing is more accurate than clinician administered Binax rapid diagnostic tests for SARS-CoV-2 infection, if N95 masks need a yearly fitting, how SARS-CoV-2 vaccination impacts the prevalence of long COVID, reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, why determining the exact number of long COVID incidences is challenging, how the incidence and predictors for fatiguing illness following SARS-CoV-2 infec

TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Fatal case of Alaskapox (AK Beacon) MERS in Kenya (Emerg Inf Dis) Diagnostic tests for Nipah and Lassa (CEPI) Measles in Arizona and Minnesota HCV-derived circular RNAs (PNAS) Resident memory CD8 T cells prevent respiratory virus transmission (Nature) Letters read on TWiV 1089 1:24:33 Timestamps by Jolene. Thanks

In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK’s RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibody response, cardiovascular consequences of influenza infection, mortality of chikungunya virus infection, if an alternative vaccination schedule impacts the anti-SARS-CoV-2 immune response, dispels the myth that increased mortality correlated with the first vaccine dose, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how manage long COVID including prevent burnout and compassion fatigue of caring for long COVID patients, whether the

TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Infant rhinovirus bronchiolitis contribution to hospital bed and vent use (JAMA Net Open) Onradivir new influenza antiviral (Lancet) Oropouche fever in Brazil (PAHO) Maryland and Ohio measles Repealing school vaccina

In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiveness of a monovalent XBB.1.5 against disease resulting from infection with Omicron variants, whether vaccination in the same or opposite arms effect antibody protection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how SARS-CoV-2 infection may alter one’s sleep patterns, what the health and economic burdens of mild disease are, and if there are predictors for recovery from fatigue and cognitive deficits following SARS-CoV-2 infect

TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Pig virus imperils food security in Borneo (Science) Measles outbreaks in UK and Europe (Nature) Fatal Nipah virus infections in Bangladesh (CIDRAP) Yellow fever outbreak in Sudan (Crisis24) COVID-19 influenced by type of immunodeficiency (Sci Transl Med) Intestinal microbiota programming of alveola

In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses the safety of the prefusion RSV vaccine, if high or moderate dose of the quadrivalent influenza vaccine is better for protection against hospitalization, summarizes the new WHO COVID guidelines, revisits how to prevent pathogen transmission in healthcare setting, the under use of COVID oral antiviral and what occurs in persistently SARS-CoV-2 infected cells in culture after antiviral treatment, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how inflammatory markers change correlate with death when in ICU and if cognitive slowing is part of long COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron 

TWiV reviews global measles outbreaks, toilet-generated aerosols that spread viruses, highly effective prevention of invasive cervical cancer by HPV vaccination, and design of improved adenovirus-associated viral vectors using machine learning. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Jay Nelson obituary Measles outbreak in Europe and Central Asia (UNICEF) Closing the toilet lid doesn’t reduce virus aerosols (Am J Inf Control) NASA’s ingenuity helicopter mission ends (NASA) HPV vaccine prevents invasive cervical cancer (J NCI) Designing AAV vectors with machine learning (Sci Adv) Letters read on TWiV 1083 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Asian girl building a life

In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, before discussing viral transmission to adults in healthcare setting, the recently EUA approved protein based COBREVAX vaccine, reviews quarantine guidelines, the use of simnotrelivr for mild to moderate COVID-19, how viral RNA may persist in your cell culture dish following antiviral therapy, continues to dispel the myth of viral rebound, how to pay for Paxlovid, , when to use steroids and the benefits of convalescent plasma, how Paxlovid may prevent long COVID and how complement dysfunction may lead to thromboinflammation during long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Articles and graphs cited in TWIV CU 1080 Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveill

TWiV reviews the latest virology news, how infection with a plant virus causes insect to grow long wings, and reverse zoonoses of 2009 H1N1 pandemic influenza viruses in US swine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Midwife gave children pellets instead of vaccines (NY Times) Vaccine derived poliovirus circulation in Indonesia (WHO) 9th case of measles in Philadelphia (City of Philadelphia) Measles exposure warning northern Virginia (Virginia DOH) China lab sequenced SARS-CoV-2 genome 2 weeks before release (WSJ) Wisconsin bill to restrict gain of function experiments (Science) Virus infection of insects causes long wings (PNAS) Reverse zoonoses of influen

In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing vaccine effectiveness in children and adolescents, how the pandemic impacted the socioemotional development of infants and toddlers, continues to dispel the myth of viral rebound, how to pay for Paxlovid, reviews quarantine guidelines, when to use steroids and the benefits of convalescent plasma, examines the role of immune aberrations in long COVID and how vaccination may protect against developing long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend(CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Remember when COVID was bad? (Wired

TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Global dengue cases rise markedly (WHO) Measles outbreak in Philadelphia (Phil Health Dept) Viruses and organomineralization of travertine (Sci Rep) Neutralizing antibodies and clearance of HCV infection (Immunity) Letters read on TWiV 1079 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Global climate highlights 2023 and 7 new songs you should hear Brianne – Stuff you should kno

In his weekly clinical update, Dr. Griffin reviews recent measles outbreaks, prequalification of nOPV2 by the WHO and most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing COVID-19 deaths linked to SNPs in C-reactive protein, spread of recent viral variants, how early vaccination reduced hospitalization of those infected with XBB.1.5, reviewed quarantine guidelines, how oral antivirals reduce hospitalizations, dissociation of antiviral treatment from infection rebound, and long COVID, deaths due to administration of hydroxychloroquine, muscle abnormalities and extreme fatigue in individuals with long COVID-19 and how the economics of where you live make long COVID-19 more severe. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode A national measles campaign (CDC) A nation of measles (CDC) The measles unvaccinated in NY (CNN) Philadelphia’s measles story (Phil