Future Science Group

In this special episode of Talking techniques, one of two recorded at Neuroscience 2022, we speak to Tim Harris (Howard Hughes Medical Institute, VA, USA). Tim is the creator of Neuropixels, neural recording probes inserted into the brains of animal models, which allow researchers to collect signals from hundreds of individual neurons in different brain regions simultaneously over extended periods of time. Here, he shares the story behind his creation and details how they have changed the data collection landscape in Neuroscience. Tim also considers every inventor’s greatest concern: has his invention led to purely positive outcomes for the field? By enabling the collection of huge datasets have Neuropixels led to studies that bury findings in vast swathes of data or have they enabled researchers to collect enough information to discover the emphatic truth? Listen now to find out Tim’s opinions on these contentious debates in neuroscience and get key tips for utilizing neuropixels!  Contents:Introduct

In this In the Zone podcast, we explore how precision oncology is currently utilized in the bioanalytical field, the use of liquid biopsies to support these studies and the major challenges impacting drug development.

Hello and welcome to the latest episode of OC Talks, the podcast from Oncology Central. I am Jade Parker, Senior Editor of Oncology Central. Today I am joined by Laetitia Decroix Guilloux, Vice President of Oncology and EMEA Commercial Strategy Lead at Janssen, to discuss the patient journey through lung cancer, examine the lung cancer paradigm, and how the cancer research community can holistically address unmet needs in cancer.

In this Tech blast episode, we talk CAR-T cell development for cancer immunotherapies with Ritwika Biswas, Product Scientist for Sino Biological. We cover some of the latest developments in the field, the advantages of CAR-T over other immunotherapies and selecting the perfect CAR-T antigen, amongst a whole host of different aspects in the field. Contents Introduction: 00:00-00:30 Core principles of cancer immunotherapy: 00:30-02:00 Explaining cancer immunity: 02:00-03:20 Distinguishing CAR-T from native T cells: 03:20-04:40 CAR-T antigen targets: 04:40-06:00 Techniques for engineering CAR-T cells: 06:00-08:00 Introducing off the shelf CAR-T cells: 08:00-09:45 Addressing challenges in off the shelf CAR-T: 09:45-11:30 Current status of CAR-T therapies: 11:30-12:55 Advantages of CAR-T cell therapy over other immunotherapies: 12:55-15:25 The future of CAR-T: 15:10-18:10

NNM-2021-0076 podcast by Future Science Group

In this interview we explore what minimal residual disease (MRD) is in hematological malignancies and how MRD is currently monitored. The interviewees also explain their recent research published in Nanomedicine, which investigates a novel tool to monitor hematological malignancies.

This month on Editor’s Picks, hear about the impacts of aerobic exercise on tumor microenvironments, the science behind female pleasure, how bacteria could be used to make whipped cream and the bacteria that could survive 280 million years on Mars!

In this Tech Blast episode supported by Sartorius (Göttingen, Germany), we talk to Daryl Cole about cell line development (CLD), some of its challenges and a possible solution: the Octet Bio-Layer Interferometry (BLI) system. Daryl Cole is a Scientist in the Bio Applications Team at Sartorius with extensive experience in a range of fields; he offers insights into the possible applications of CLD and how to get the most out of the Octet BLI system.

In this episode of Editor’s Picks, we bring you the latest news in the life sciences including DishBrain, a dish of neurons that can play a computer game of table tennis, and click chemistry, which was awarded the Nobel Prize in Chemistry this year.

In this podcast, we spoke with Katja Piltti from University of California, Irvine (USA) to learn about the importance of quality control in regenerative medicine. We discussed how automated cell culture monitoring and quality control can address changing needs in the transition from preclinical research to cGMP production.

Organoids are transforming the way we approach the drug discovery pipeline. In this Tech Blast episode, Ritwika Biswas, Product Scientist at Sino Biological (Beijing, China), explains why drug discovery needs new methods and how organoids can help. Find out the importance of growth factors in the development of organoids for drug discovery, the challenges associated with their use and the impact of organoid biobanks on the field in this 15-minute overview of the landscape of organoids in drug discovery. Contents: Introductions: 00:00-00:28 Reviewing the drug discovery process: 00:28-02:45 Traditional methods used for target validation and drug screening: 02:45-05:20 Challenges associated with traditional methods: 05:20-07:00 How organoids can be used to address these challenges: 07:00-09:30 The importance of growth factors in organoid development: 09:30-10:50 Challenges in the utilization of organoids in drug discovery: 10:50-13:30 Organoid biobanks: 13:30-14:40 The impact of organoids in precision medi

In this Tech Blast episode, we discuss multiplex PCR methods, their challenges and advantages, and the tools being developed to advance multiplexing capabilities. Marco Bianchi, Product Manager at Bio-Rad Laboratories (CA, USA), provides an insight into what role multiplexing plays in research.

In this month's episode of Editor's Picks, we’ve got articles on magnetic synthetic cells, the synthesis of the most complete artificial microbiome yet and how a key protein in human fertilization was identified.

In this episode of the Talking Techniques podcast, we explore microbiomes and the techniques used to profile them. Get an overview of the different techniques’ working principles, their pros and cons and the different applications that they are best suited to. Providing an expert insight into this field is Annabelle Damerum, Microbiome R&D Scientist at Zymo Research. Annabelle reveals some key tips best practice when profiling the microbiome and details the importance of an emerging aspect of the field: the vaginal microbiome. Contents: Into: 00:00-01:50Why it is important to profile microbiomes. 01:50-04:15Key applications of microbiome profiling: 04:15-06:10Techniques used to profile the microbiome and their working principles: 06:10-09:20Targeted sequencing: 06:10-08:00Shotgun metagenomics: 08:00-09:00Metatranscriptomics: 09:00-9:15The strengths and limitations of these techniques: 09:12-             Targeted sequencing: 09:20-10.15Shot

As the cell and gene therapy industry expands further into commercialization, researchers, developers and manufacturers are growing increasingly aware of the need for specialized ancillary materials in the production of therapeutics. High-quality ancillary materials are often neglected during the early stages of development due to perceived cost, but conversion at later stages of development can be prohibitive and detrimental to program success.  In this podcast, in association with Sexton Biotechnologies (now part of BioLife Solutions; WA, USA), Steve Elimann of Orbsen Therapeutics (Galway, Ireland) and Steven Thompson of Sexton Biotechnologies discuss the challenges of variability in producing cell therapeutics, and how using consistent reagents from reliable manufacturers can tackle this challenge. We also dive deep into the importance of gaining and maintaining trustworthy partners early in your cell therapy journey and how this can influence the overall success of your final product.

In this special episode of Talking Techniques, brought to you from the Federation of European Neuroscience Societies Forum (FENS; 9th–13th July 2022), an expert panel discuss their research into the relationship between the gut–brain axis and addiction. The panel features Benjamin Boutrel (Lausanne University Hospital; Switzerland), Lorenzo Leggio (NIH Intramural Research Program; MD, USA) and Nathalie Delzenne (University of Louvain; Louvain-la-Neuve, Belgium), who discuss their current research into the role of the microbiota in alcohol addiction, if this work could be translated into the clinic, and if similar processes are at play in other addictions, such as food and cocaine. The discussion also features an audience Q&A, which explores the microbial relationship between mother and fetus, and social factors in addiction. Contents:Introduction: 00:00–01:35Introduction to panelists: 01:35–03:40Techniques being used to investigate the relationship between the gut and addiction: 03:40–0

In this Tech Blast episode, we discuss all things organoids with Ritwika Biswas, Product Specialist at Sino Biological US Inc (PA, USA). Ritwika provides an overview of what are organoids are, how reconbinant growths factors are utlized in their development, the benefits 3D organoid systems offer over 2D cell culture systems and the various applications organoids can be used for. Ritwika also explores the challenges that remain in organoid research and how these can be overcome, as well as what the future holds for these models. Contents: Introduction: 00:00–00:30 What are organoids? 00:30–01:05 Existing organoids: 01:05–02:00 Generating organoids and cell culture methods: 02:00–04:30 Applications of organoids: 04:30–06:10 Comparing 3D and 2D culture systems: 06:10–07:40 Reproducibility, matrigels and increasing complexity: 07:40–09:50 The future of organoids: 09:50–12:20

Hello and welcome to today’s latest episode of OC Talks Podcast by Oncology Central. My name is Jade Parker, Senior Editor of Oncology Central, and I am joined by Volkmar Mϋller from University Medical Center Hamburg-Eppendorf in Germany. Today we are going to discuss HER2-positive breast cancer including the unmet needs of the disease, and our hopes for the future.

In this Tech Blast episode, BioTechniques' Digital Editor, Annie Coulson, discusses single domain antibodies with ProSci’s Andy Lee, Lead Scientist of the Single Domain Antibody Program, and David Eling, Director of Business Development. Andy and David describe what single domain antibodies (sdAbs) are, including their unique characteristics, such as their small size. They then go on to explore the applications of sdAbs, from increasing resolution in imaging studies, to developing antidotes for snake venom. Listen to this episode to get an overview of sdAbs, how they could be incorporated into your research and their link to llamas. Contents: Introductions: 00:00–01:25 What are single domain antibodies? 01:25–3:05 Applications of single domain antibodies: 03:05–05:05 Unique characteristics of sdAbs: 05:05–07:55 sdAbs for SARS-CoV-2: 07:55–08:35 sdAbs for therapeutics and diagnostics: 08:35–11:25 Unique applications, including biosensors and animal feed: 11:25–12:50 Working with researchers to develop sdAbs:

In this Tech Blast episode, our Digital Editor Annie Coulson talks with Carlo Messina, Senior Director for Oncology in Global Development and Medical Affairs at Roche (Basel, Switzerland), about the use of comprehensive genomic profiling (CGP) in cancer research. CGP can obtain more information about a tumor from a smaller biospecimen compared with other genomic profiling techniques and gives oncologists more tools for treating patients. Carlo talks about the applications of CGP, including detecting genomic aberrations in the bloodstream, and the future of this technique.