The Bob Harrington Show

Bob Harrington, Erin Michos, and Brahmajee Nallamothu discuss how the publish or perish culture can lead to sloppy research and the need for alternative models to measure success in academic medicine. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington With Great Power Comes Great Responsibility Big Data Research From the National Inpatient Sample https://doi.org/10.1161/CIRCOUTCOMES.117.003846 Adherence to Methodological Standards in Research Using the National Inpatient Sample https://doi.org/10.1001/jama.2017.17653 Publish or Perish: Where are we heading? https://pubmed.ncbi.nlm.nih.gov/24778659 The Kardashian Index of Cardiologists: Celebrities or Experts? https://doi.org/10.1016/j.jaccas.2019.11.068 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscap

Bob Harrington and Mike Gibson discuss two of the hottest topics in cardiology and medicine for 2023: a proposed alternative to the maintenance of certification process, and artificial intelligence. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Cardiovascular Organizations Pursue New, Independent Medical Board https://www.acc.org/About-ACC/Press-Releases/2023/09/21/15/02/Cardiovascular-Organizations-Pursue-New-Independent-Medical-Board The National Board of Physicians and Surgeons https://nbpas.org/ Level of Scientific Evidence Underlying the Current American College of Cardiology/American Heart Association Clinical Practice Guidelines https://doi.org/10.1161/CIRCOUTCOMES.118.005293 Validation of a Speech Analysis Application to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients https://www.abstractsonline.com/pp8/?_ga=2.17782015.7532578.1693882428-1949139275.1663003561#!/10871/prese

For this year's review, Bob Harrington and Mike Gibson revisit the major cardiology conferences -- from ACC in New Orleans to AHA in Philly. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington ACC 2023 Top Trials - Bempedoic Acid Cuts CV Events in Statin-Intolerant Patients: CLEAR Outcomes https://www.medscape.com/viewarticle/989100 - Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients - Phase 2b Randomized Trial of the Oral PCSK9 Inhibitor MK-0616 https://www.jacc.org/doi/10.1016/j.jacc.2023.02.018 ACC/WCC 2023 Collection Page https://www.medscape.com/viewcollection/36966 ESC 2023 Top Trials - Wegovy Scores HFpEF Benefits in People With Obesity https://www.medscape.com/viewarticle/995844 - Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2306963 - Acoramidis Shows Encouraging Results in ATTR Cardiomyopathy htt

Bob Harrington and Manesh Patel discuss sudden cardiac death in athletes and the importance of the chain of survival. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington COVID and the Athlete's Heart https://www.medscape.com/viewarticle/945282 Outcomes Registry for Cardiac Conditions in Athletes https://doi.org/10.1161/JAHA.122.029052 2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy https://doi.org/10.1161/CIR.0000000000000937 Point-of-care screening for HFrEF using artificial intelligence during ECG-enabled stethoscope examination https://doi.org/10.1016/s2589-7500(21)00256-9 International recommendations for electrocardiographic interpretation in athletes https://doi.org/10.1093/eurheartj/ehw631 Elevation of Cardiac Troponins After Endurance Running Competitions https://doi.org/10.1161/CIRCULATIONAHA.118.034655 Vigorous Exercise in Patients With Hypertrophic Car

Bob Harrington interviews Jag Singh about the COVID journey that led to his book, Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine. https://www.jagsinghmd.com/book COVID-19 Hits Physician Couple: Dramatically Different Responses https://www.medscape.com/viewarticle/928530 Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The QT-logs study https://doi.org/10.1016/j.ijcard.2021.01.002 The Care of the Patient https://doi.org/10.1001/jama.1927.02680380001001 Advancements and future directions in the teamwork, targets, technology, and tight control-the 4T study: improving clinical outcomes in newly diagnosed pediatric type 1 diabetes https://doi.org/10.1097/mop.00000000000011

Robert Harrington, MD and Jenine John, a cardiologist and machine learning research fellow discuss what you need to know about AI and ML in healthcare and where to find some helpful resources. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington 'One Brave Idea' Recipient on Predicting Who Will Develop CAD https://www.medscape.com/viewarticle/874536 Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection https://doi.org/10.1161/circulationaha.121.058696 Application of Artificial Intelligence to the Electrocardiogram https://doi.org/10.1093/eurheartj/ehab649 Using Machine Learning to Detect Problems in ECG Data Collection https://www.cinc.org/archives/2011/pdf/0437.pdf Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs https://doi.org/10.1161/CIRCEP.119.007284 External Validation of a Widely Implemented Proprietary Sepsi

Bob Harrington talks to two former colleagues who made a mid- and senior-career switch to pharma and digital tech, respectively. How did they make this decision and what advice do they have for others? This podcast is intended for healthcare professionals only. To read a transcript or to comment https://www.medscape.com/author/bob-harrington Jeff Bezos - Regret Minimization https://www.youtube.com/watch?v=-qPii5ACVYw You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Trials on heart failure, hypertension and lipid-lowering drugs, and the evolution of antithrombin and antiplatelet therapy are discussed in part 2 of cardiologists Bob Harrington and Mike Gibson's annual review. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Lipid Lowering Safety, Tolerability and Efficacy of Up-Titration of Guideline-Directed Medical Therapies for Acute Heart Failure (STRONG-HF): A Multinational, Open-Label, Randomised, Trial https://doi.org/10.1016/S0140-6736(22)02076-1 Why Combination Lipid-Lowering Therapy Should Be Considered Early in the Treatment of Elevated LDL-C for CV Risk Reduction https://www.acc.org/latest-in-cardiology/articles/2022/06/01/12/11/why-combination-lipid-lowering-therapy-should-be-considered Incidental Coronary Artery Calcium: Opportunistic Screening of Prior Non-gated Chest CTs to Improve Statin Rates (NOTIFY-1 Project) https://www.ahajournals.org/doi/10.1161/CIRC

In part 1 of their annual review, cardiologists Bob Harrington and Mike Gibson discuss in-person meetings, wearables and AI, COVID lessons for medical research, and the growth of RCTs from China. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington COVID Therapies Therapeutic Anticoagulation With Heparin in Noncritically Ill Patients With Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMoa2105911 Effect of Intermediate/High Versus Low Dose Heparin on the Thromboembolic and Hemorrhagic Risk of Unvaccinated COVID-19 Patients in the Emergency Department https://doi.org/10.1186/s12873-022-00668-8 Two Old Meds and a DOAC a Bust Across Range of COVID Severity: The ACT Trials https://www.medscape.com/viewarticle/980049 Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial http://jamanetwork.com/article.aspx?doi=10.1001/jama.2022.18590 FD

Drs Bob Harrington and Betty Raman discuss the cardiovascular impact and long-term sequelae of COVID-19, the potential biology behind multisystem effects, and ongoing research. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Medium-term Effects of SARS-CoV-2 Infection on Multiple Vital Organs, Exercise Capacity, Cognition, Quality of Life and Mental Health, Post-Hospital Discharge https://doi.org/10.1016/j.eclinm.2020.100683 Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection https://doi.org/10.1016%2Fj.jacc.2020.06.007 Outcomes Among Confirmed Cases and a Matched Comparison Group in the Long-COVID in Scotland Study https://doi.org/10.1038/s41467-022-33415-5 Long COVID: Post-Acute Sequelae of COVID-19 With a Cardiovascular Focus https://doi.org/10.1093/eurheartj/ehac031 Cardiovascular Disease and COVID-19: A Consensus Paper From the ESC Working Group on Coronary Pathophy

Do cardiologists from the AFFIRM generation treat AF less aggressively than the EAST-AFNET generation? Bob Harrington and Jonathan Piccini discuss this and upcoming trials on atrial fibrillation. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation (AFFIRM) https://www.nejm.org/doi/full/10.1056/NEJMoa021328 Early Rhythm-Control Therapy in Patients with Atrial Fibrillation (EAST-AFNET 4) https://www.nejm.org/doi/10.1056/NEJMoa2019422 Early AF Rhythm-Control Advantage Climbs With Comorbidity Burden: EAST-AFNET4 https://www.medscape.com/viewarticle/979627 Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB) https://clinicaltrials.gov/ct2/show/NCT05130268 Generalizability of the EAST‐AFNET 4 Trial: Assessing Outcomes of Early Rhythm‐Control Therapy in Patients With A

Dr Bob Harrington talks with Drs Michelle Albert and Eldrin Lewis about the Association of Black Cardiologists' diversity scorecard for cardiovascular training programs. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington The ABC Updates its CV DIBS Rankings | Association of Black Cardiologists https://abcardio.org/recent-news/the-abc-updates-its-cv-dibs-rankings/ FDA Takes Important Steps to Increase Racial and Ethnic Diversity in Clinical Trials https://www.fda.gov/news-events/press-announcements/fda-takes-important-steps-increase-racial-and-ethnic-diversity-clinical-trials Gender Diversity in Cardiovascular Clinical Trial Research Begins at the Top https://www.jacc.org/doi/abs/10.1016/j.jacc.2022.01.001 A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops https://www.nejm.org/doi/full/10.1056/NEJMoa1717250 At Black Barbershops, BP Reductions Still in Style at 1 Year https://www.medscap

Robert A. Harrington interviews LaShyra Nolen, a medical student and the 2021 recipient of the American Medical Student Association's Racial Justice in Medicine Award. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington How Medical Education Is Missing the Bull's-eye https://doi.org/10.1056/NEJMp1915891 This Is What I Want To Tell My White Professors When They Ask, 'How Are You Today?' https://www.huffpost.com/entry/black-medical-student-wants-white-professors-to-know_n_5ed91238c5b6e0feefc26315 Statue of Controversial Surgeon to Be Moved From Central Park https://www.medscape.com/viewarticle/891413 A Rift Over Carl Linnaeus Shows We Shouldn't Idolise Scientists https://science.thewire.in/the-sciences/carl-linnaeus-entomological-society-of-america-great-man-theory-progress/ Running Away from Drapetomania: Samuel A. Cartwright, Medicine, and Race in the Antebellum South https://muse.jhu.edu/article/699875 What Le

Bob Harrington interviews fellow cardiologist Jacqueline Tamis-Holland, vice chair of the recent ACC/AHA revascularization guidelines, who takes us inside the process. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization https://doi.org/10.1016/j.jacc.2021.09.006 Evidence Based Medicine: What It Is and What It Isn't https://doi.org/10.1136/bmj.312.7023.71 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: https://doi.org/10.1161/CIR.0000000000000404 Ticagrelor With or Without Aspirin in High-Risk Patients After PCI https://doi.org/10.1056/NEJMoa1908419 Surgical Groups Push Back Against New Revascularization Guidelines https://www.medscape.com/viewarticle/966153 Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://doi.org/10.1161/CIRCULATIONA

Robert Harrington, MD, interviews Ziyad Al-Aly, MD, about his recent paper in Nature Medicine focused on the long-term cardiovascular effects of COVID-19. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Robert A. Harrington, MD, Arthur L. Bloomfield Professor; Chair, Department of Medicine, Stanford University; Chair, Department of Medicine, Stanford Medical Center, Stanford, California Ziyad Al-Aly, MD, Chief of Research and Development, VA St. Louis Health Care System, St. Louis, Missouri COVID-19 and Long-term Health Long-Term Cardiovascular Outcomes of COVID-19 https://doi.org/10.1038/s41591-022-01689-3 High-Dimensional Characterization of Post-acute Sequelae of COVID-19 https://doi.org/10.1038/s41586-021-03553-9 Risks of Mental Health Outcomes in People With COVID-19: Cohort Study https://doi.org/10.1136/bmj-2021-068993 Kidney Outcomes in Long COVID https://doi.org/10.1681/ASN.2021060734 I'm 26. Coronavir

Trials on lowering salt consumption and treating hypertension in the community impressed Drs Harrington and Gibson in this discussion of the best public health research of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington CV Public Health Trials Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS) https://doi.org/10.1016/j.ahj.2019.12.020 A Cluster Randomized Trial of a Village Doctor-Led Intervention on Blood Pressure Control: China Rural Hypertension Control Project https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18155 A Remotely Delivered Hypertension and Lipid Program in 10,000 Patients Across a Diverse Health Care Network https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18153 COVID-19

This podcast is intended for US healthcare professionals only. To read a full transcript of this episode or to comment please visit: https://www.medscape.com/viewarticle/963475 Drs Harrington and Gibson provide their annual roundup of what they consider the key cardiovascular trials of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Antiplatelet Therapy Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease https://doi.org/10.1056/NEJMoa2102137 Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk https://doi.org/10.1056/NEJMoa2108749 Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI https://doi.org/10.1001/jama.2019.8145 Aspirin Versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention (HOST-EXAM): An Investigator-Ini

Instead of trying therapies and hoping for the best, the RECOVERY trial investigators designed randomized trials to test which therapeutics were truly effective for COVID-19. Dr Harrington interviews lead investigator Martin Landray, MB ChB, PhD. To read a transcript or to comment: https://www.medscape.com/author/bob-harrington The Bob Harrington Show is intended for healthcare professionals. RECOVERY Trial Website and Some Publications Randomized Evaluation of COVID-19 Therapy https://www.recoverytrial.net/ Dexamethasone in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/nejmoa2021436 Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial https://doi.org/10.1016/S0140-6736(20)32013-4 Remdesivir for the Treatment of Covid-19 — Final Report https://www.nejm.org/doi/full/10.1056/nejmoa2007764 Dexamethasone in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/nejmoa2021436 Effect of Hydr

A genomics giant with a family history of heart disease and an Olympic athlete accused of cheating are just two of the medical mysteries unraveled by DNA analysis. Bob Harrington interviews Euan Ashley, author of The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them (https://us.macmillan.com/books/9781250234995), who was inspired to write the book after watching an interview between "fellow nerds" Atul Gawande and Barack Obama. To read a transcript or to comment https://www.medscape.com/author/bob-harrington The Book The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them https://us.macmillan.com/books/9781250234995 The People Stephen Quake Clinical assessment incorporating a personal genome https://doi.org/10.1016/s0140-6736(10)60452-7 Leilani Graham https://www.leilanirgraham.com/ Eero Mäntyranta https://theolympians.co/2018/01/22/eero-mantyranta-the-ruddy-cheeks-and-the-genetic-advantange-of-a-cross-country-skiing-legend-from-finland/ You may also like: Medscape

What is the incidence of post-COVID myocarditis and when is it safe to return to play? Bob Harrington and Manesh Patel discuss our evolving understanding of how SARS-CoV-2 effects the hearts of athletes and weekend warriors. To read a transcript or to comment https://www.medscape.com/author/bob-harrington Early Studies Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) https://doi.org/10.1001/jamacardio.2020.3557 Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection https://doi.org/10.1001/jamacardio.2020.4916 Pooled autopsy https://www.medscape.com/viewarticle/944496 Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week https://doi.org/10.1016/j.jacc.2020.11.031 Lake Louise Criteria https://pubmed.ncbi.nlm.nih.gov/30545455/ Recognition and Initial Management of Fulminant Myocarditis A Scientific Statement From the American Heart Association https:/