Hs Info

MPS II (Hunter syndrome) is one of 11 mucopolysaccharidoses (MPS) diseases: a group of rare, genetic, metabolic disorders. In this episode, Professor Roberto Giugliani (Department of Genetics of the Federal University of Rio Grande do Sul and Chief of the Medical Genetics Service of Hospital de Clinicas de Porto Alegre, Brazil) discusses the pitfalls of recognising MPS II, a rare and progressive disease. MPS II is difficult to diagnose due to the large heterogeneity in clinical presentations and symptom overlap with common childhood complaints; Professor Giugliani highlights key red flag symptoms for healthcare professionals to be aware of that might prompt clinical suspicion of an MPS disorder. He describes the current diagnostic methods used, including urinary GAG testing, enzyme assays and genetic testing, and discusses the future of GAG testing. He describes the referral network in Brazil as an example to promote earlier referral for testing and earlier diagnosis. This podcast series was initiated, organi