Sage Orthopaedics

The effect of platelet-rich plasma (PRP) on chondrocytes has been studied in cell and tissue culture, but considerably less attention has been given to the effect of PRP on synoviocytes. Fibroblast-like synoviocytes (FLS) compose 80% of the normal human synovium and produce cytokines and matrix metalloproteinases that can mediate cartilage catabolism. Treatment of synovial cells with LR-PRP and RBCs resulted in significant cell death and proinflammatory mediator production.   Click here to read the article.